Reaction Details |
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Target | Fibroblast growth factor receptor 2 |
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Ligand | BDBM161461 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Measurement of Inhibitory Effect on FGFR2 Kinase Activity |
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IC50 | 270±n/a nM |
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Citation | Sootome, H Therapeutic agent for FGFR inhibitor-resistant cancer US Patent US10835536 Publication Date 11/17/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Fibroblast growth factor receptor 2 |
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Name: | Fibroblast growth factor receptor 2 |
Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 |
Type: | Enzyme |
Mol. Mass.: | 92015.45 |
Organism: | Homo sapiens (Human) |
Description: | P21802 |
Residue: | 821 |
Sequence: | MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
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BDBM161461 |
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n/a |
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Name | BDBM161461 |
Synonyms: | US10124003, Ref. Ex. Compound 2 | US10835536, Ref. Ex. Comp 2 | US10894048, Ref. Ex Comp. 2 | US9108973, Ref 2 |
Type | Small organic molecule |
Emp. Form. | C18H16N4 |
Mol. Mass. | 288.3464 |
SMILES | Nc1nccn2c(nc(C#Cc3ccccc3)c12)C1CCC1 |
Structure |
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