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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM396944 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TAM Enzymatic Assay | ||
| IC50 | <5±n/a nM | ||
| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US10844069 Publication Date 11/24/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM396944 | |||
| n/a | |||
| Name | BDBM396944 | ||
| Synonyms: | N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide | US10442810, Example 7 | US10844069, Example 7 (cisisomer) | US9981975, Example 7 (cis isomer) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H28N6O3 | ||
| Mol. Mass. | 520.5817 | ||
| SMILES | Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@H](O)CC1 |r,wU:32.36,35.40,(-5.98,12.64,;-6.45,11.17,;-7.96,10.85,;-8.44,9.39,;-7.41,8.24,;-5.9,8.56,;-4.65,7.66,;-3.41,8.56,;-3.88,10.03,;-3.11,11.36,;-3.88,12.7,;-3.11,14.03,;-1.57,14.03,;-.8,15.36,;.74,15.36,;1.51,14.03,;1.51,16.7,;.74,18.03,;1.51,19.36,;3.05,19.36,;3.82,18.03,;5.36,18.03,;6.13,16.7,;7.67,16.7,;8.44,18.03,;7.67,19.36,;6.13,19.36,;3.05,16.7,;3.82,15.36,;-.8,12.7,;-1.57,11.36,;-5.42,10.03,;-4.65,6.12,;-5.99,5.35,;-5.99,3.81,;-4.65,3.04,;-4.65,1.5,;-3.32,3.81,;-3.32,5.35,)| | ||
| Structure | 
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