| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Ligand | BDBM50158326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | fluorescence polarization competition assay (FPCA) |
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| Ki | 190±20 nM |
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| Citation |  Fletcher, S; Lanning, M; Chen, L Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof US Patent US10858316 Publication Date 12/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
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| Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
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| Mol. Mass.: | 26053.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_510901 |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50158326 |
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| n/a |
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| Name | BDBM50158326 |
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| Synonyms: | CHEMBL3781669 | US10858316, Compound 3bg |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15Cl2NO6S |
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| Mol. Mass. | 504.339 |
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| SMILES | OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)Nc1ccc(Oc2ccc(Cl)cc2Cl)cc1 |
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| Structure | 
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