Reaction Details |
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Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Ligand | BDBM473829 |
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Substrate/Competitor | n/a |
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Meas. Tech. | fluorescence polarization competition assay (FPCA) |
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Ki | 290±50 nM |
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Citation | Fletcher, S; Lanning, M; Chen, L Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof US Patent US10858316 Publication Date 12/8/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
Mol. Mass.: | 26053.63 |
Organism: | Homo sapiens (Human) |
Description: | gi_510901 |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM473829 |
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n/a |
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Name | BDBM473829 |
Synonyms: | US10858316, Compound 3bk |
Type | Small organic molecule |
Emp. Form. | C30H24ClNO6S |
Mol. Mass. | 562.033 |
SMILES | Cc1cc(Oc2ccc(cc2)N(C2C=CC=C2)S(=O)(=O)c2cc(C(O)=O)c(O)c3ccccc23)cc(C)c1Cl |c:14,16| |
Structure |
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