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TargetPantetheinase
LigandBDBM475868
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 0.200±n/a nM
Citation Godbout, CFleck, MTKoolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent US10864201 Publication Date 12/15/2020
More Info.:Get all data from this article,  Assay Method
 
Pantetheinase
Name:Pantetheinase
Synonyms:Pantetheine hydrolase | Tiff66 | VNN1 | VNN1_HUMAN | Vanin-1 | Vascular non-inflammatory molecule 1
Type:Enzyme Catalytic Domain
Mol. Mass.:57002.46
Organism:Homo sapiens (Human)
Description:O95497
Residue:513
Sequence:
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
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  Blast E-value cutoff:
BDBM475868
n/a
NameBDBM475868
Synonyms:N-[(3S)-1-[(2R)-2-(4-Fluorophenyl)-2-methyl-1H,2H,3H-pyrrolo[2,3-b]lpyridine-5-carbonyl]-pyrrolidin-3-yl]-N-methylacetamide | US10864201, Ex. 6
TypeSmall organic molecule
Emp. Form.C22H25FN4O2
Mol. Mass.396.4579
SMILESCN([C@H]1CCN(C1)C(=O)c1cnc2N[C@](C)(Cc2c1)c1ccc(F)cc1)C(C)=O |r|
Structure
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