Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476757

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.140±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476757

n/a

Name

BDBM476757

Synonyms:

US10870660, Compound III-019 | US11345716, Compound III-019

Type

Small organic molecule

Emp. Form.

C25H35F2N5O3

Mol. Mass.

491.5739

SMILES

Cc1nc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4ccc(OCC(C)(F)F)nc4CC3)CC2)no1 |r,wU:11.11,wD:8.7,(13.39,2.1,;11.85,2.1,;10.82,3.24,;9.41,2.61,;8.08,3.38,;6.75,2.61,;6.75,1.07,;5.41,3.38,;4.08,2.61,;2.74,3.38,;1.41,2.61,;1.41,1.07,;.08,.3,;-1.26,1.07,;-2.59,.3,;-2.48,-1.23,;-3.6,-2.28,;-5.13,-2.05,;-5.9,-3.38,;-7.44,-3.38,;-8.21,-2.05,;-9.75,-2.05,;-10.52,-.72,;-12.06,-.72,;-12.83,.62,;-12.06,-2.26,;-13.39,-1.49,;-7.44,-.72,;-5.9,-.72,;-5.33,.72,;-3.86,1.17,;2.74,.3,;4.08,1.07,;9.57,1.08,;11.08,.76,)|

Structure