Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476796

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.240±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476796

n/a

Name

BDBM476796

Synonyms:

US10870660, Compound III-244 | US11345716, Compound III-244

Type

Small organic molecule

Emp. Form.

C28H35F2N5O2S

Mol. Mass.

543.672

SMILES

Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OC4CC(F)(F)C4)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.85,-1.57,;12.08,-.23,;10.54,-.07,;10.22,1.44,;8.89,2.21,;8.89,3.75,;10.22,4.52,;11.56,3.75,;11.56,2.21,;12.7,1.18,;7.56,1.44,;7.56,-.1,;6.22,2.21,;4.89,1.44,;3.56,2.21,;2.22,1.44,;2.22,-.1,;.89,-.87,;-.45,-.1,;-1.78,-.87,;-3.05,-.01,;-4.52,-.46,;-5.09,-1.89,;-6.59,-2.21,;-6.75,-3.75,;-8.09,-4.52,;-9.42,-3.75,;-9.82,-2.26,;-11.31,-2.66,;-12.85,-2.66,;-12.4,-1.57,;-10.91,-4.14,;-5.35,-4.37,;-4.32,-3.23,;-2.79,-3.46,;-1.66,-2.41,;3.56,-.87,;4.89,-.1,)|

Structure