Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476849

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.200±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476849

n/a

Name

BDBM476849

Synonyms:

US10870660, Compound III-666 | US11345716, Compound III-666

Type

Small organic molecule

Emp. Form.

C26H32F3N5O2S

Mol. Mass.

535.625

SMILES

Cn1cc2c(ccc(F)c2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3sc(OCC(C)(F)F)nc3C2)CC1 |r,wU:17.19,wD:14.15,(12.11,-2.23,;11.34,-.9,;9.81,-.74,;9.49,.77,;8.15,1.54,;8.15,3.08,;9.49,3.85,;10.82,3.08,;12.16,3.85,;10.82,1.54,;11.97,.51,;6.82,.77,;6.82,-.77,;5.49,1.54,;4.15,.77,;2.82,1.54,;1.49,.77,;1.49,-.77,;.15,-1.54,;-1.18,-.77,;-2.51,-1.54,;-2.5,-3.08,;-3.83,-3.85,;-5.17,-3.08,;-6.63,-3.56,;-7.54,-2.31,;-9.08,-2.31,;-9.85,-.98,;-11.39,-.98,;-10.62,.36,;-12.16,.36,;-12.16,-2.31,;-6.63,-1.06,;-5.17,-1.54,;-3.83,-.77,;2.82,-1.54,;4.15,-.77,)|

Structure