Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476859

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.085±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476859

n/a

Name

BDBM476859

Synonyms:

US10870660, Compound II-005 | US11345716, Compound II-005

Type

Small organic molecule

Emp. Form.

C25H34F2N4O2S

Mol. Mass.

492.625

SMILES

Cc1ncc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4ccc(OCC(F)F)nc4CC3)CC2)s1 |r,wU:12.12,wD:9.8,(13.07,1.84,;11.53,1.84,;10.63,.6,;9.16,1.07,;9.16,2.61,;7.83,3.38,;6.5,2.61,;6.5,1.07,;5.16,3.38,;3.83,2.61,;2.5,3.38,;1.16,2.61,;1.16,1.07,;-.17,.3,;-1.5,1.07,;-2.84,.3,;-2.72,-1.23,;-3.85,-2.28,;-5.37,-2.05,;-6.14,-3.38,;-7.68,-3.38,;-8.45,-2.05,;-9.99,-2.05,;-10.76,-.72,;-12.3,-.72,;-13.07,-2.05,;-13.07,.62,;-7.68,-.72,;-6.14,-.72,;-5.58,.72,;-4.11,1.17,;2.5,.3,;3.83,1.07,;10.63,3.09,)|

Structure