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TargetD(3) dopamine receptor
LigandBDBM476862
Substrate/Competitorn/a
Meas. Tech.Binding Assay
Ki 0.120±n/a nM
Citation Tobinaga, HMasuda, KInagaki, MYonehara, MMasuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020
More Info.:Get all data from this article,  Assay Method
 
D(3) dopamine receptor
Name:D(3) dopamine receptor
Synonyms:DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:n/a
Mol. Mass.:44243.43
Organism:Homo sapiens (Human)
Description:n/a
Residue:400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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BDBM476862
n/a
NameBDBM476862
Synonyms:US10870660, Compound II-029 | US11345716, Compound II-029
TypeSmall organic molecule
Emp. Form.C24H34F2N4O3S
Mol. Mass.496.614
SMILESCc1ncc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(C)(F)F)sc4CC3)CC2)o1 |r,wU:12.12,wD:9.8,(13.21,2.3,;11.67,2.3,;10.77,1.05,;9.3,1.53,;9.3,3.07,;7.97,3.84,;6.63,3.07,;6.63,1.53,;5.3,3.84,;3.97,3.07,;2.63,3.84,;1.3,3.07,;1.3,1.53,;-.03,.76,;-1.37,1.53,;-2.7,.76,;-3.91,1.72,;-5.41,1.38,;-6.08,-.01,;-7.6,-.22,;-7.88,-1.73,;-9.21,-2.5,;-10.54,-1.73,;-11.88,-2.5,;-13.21,-1.73,;-12.65,-3.84,;-11.11,-3.84,;-6.52,-2.46,;-5.41,-1.4,;-3.91,-1.74,;-2.7,-.78,;2.63,.76,;3.97,1.53,;10.77,3.54,)|
Structure
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