Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476882

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.130±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476882

n/a

Name

BDBM476882

Synonyms:

US10870660, Compound I-071 | US11345716, Compound I-071

Type

Small organic molecule

Emp. Form.

C27H32F2N4O2S

Mol. Mass.

514.63

SMILES

CC(F)(F)COc1nc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4ncccc34)CCc2s1 |r,wU:13.12,wD:16.19,(-11.88,.36,;-11.11,-.98,;-11.11,-2.52,;-12.45,-1.75,;-9.57,-.98,;-8.8,-2.31,;-7.26,-2.31,;-6.36,-1.06,;-4.89,-1.54,;-3.56,-.77,;-2.22,-1.54,;-.89,-.77,;.44,-1.54,;1.78,-.77,;1.78,.77,;3.11,1.54,;4.44,.77,;4.44,-.77,;3.11,-1.54,;5.78,1.54,;7.11,.77,;7.11,-.77,;8.44,1.54,;8.44,3.08,;9.78,3.85,;11.11,3.08,;11.11,1.54,;12.45,.77,;12.45,-.77,;11.11,-1.54,;9.78,-.77,;9.78,.77,;-2.22,-3.08,;-3.56,-3.85,;-4.89,-3.08,;-6.36,-3.56,)|

Structure