Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476887

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.120±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476887

n/a

Name

BDBM476887

Synonyms:

US10870660, Compound I-098

Type

Small organic molecule

Emp. Form.

C24H32F2N4O2S

Mol. Mass.

478.598

SMILES

Cc1cc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4sc(nc4C3)C3CC(F)(F)C3)CC2)on1 |r,wU:8.7,wD:11.11,(13.03,1.57,;11.5,1.41,;10.47,2.55,;9.06,1.93,;7.73,2.69,;6.39,1.93,;6.39,.38,;5.06,2.69,;3.73,1.93,;3.73,.38,;2.39,-.38,;1.06,.38,;-.27,-.38,;-1.61,.38,;-2.94,-.38,;-2.94,-1.93,;-4.28,-2.69,;-5.61,-1.93,;-7.07,-2.4,;-7.98,-1.15,;-7.07,.09,;-5.61,-.38,;-4.28,.38,;-9.52,-1.15,;-10.61,-.07,;-11.7,-1.15,;-13.03,-.38,;-13.03,-1.93,;-10.61,-2.24,;1.06,1.93,;2.39,2.69,;9.22,.39,;10.73,.07,)|

Structure