| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
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| Ligand | BDBM477774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Kinase Assay |
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| IC50 | 0.340±n/a nM |
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| Citation |  Romero, FA; Kirschberg, TA; Halcomb, R; Xu, Y Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias US Patent US10889571 Publication Date 1/12/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [64-515] |
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| Name: | Tyrosine-protein kinase ABL1 [64-515] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51539.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 64-515 |
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| Residue: | 452 |
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| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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| BDBM477774 |
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| n/a |
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| Name | BDBM477774 |
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| Synonyms: | US10889571, Example 118 | US20240101536, Example 118 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14ClF4N5O2 |
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| Mol. Mass. | 479.815 |
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| SMILES | Cn1c(nc2cc(cc(-c3cncnc3)c12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1)C(F)F |
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| Structure | 
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