| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [49-170] |
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| Ligand | BDBM480525 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| IC50 | 3.00±n/a nM |
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| Citation |  Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent US10899769 Publication Date 1/26/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [49-170] |
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| Name: | Bromodomain-containing protein 4 [49-170] |
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| Synonyms: | BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 14593.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 49-170 (BRD4-BD1) |
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| Residue: | 122 |
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| Sequence: | ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMG
TIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
TE
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| BDBM480525 |
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| n/a |
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| Name | BDBM480525 |
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| Synonyms: | 3-Cyclopropyl-1-(3-(difluoromethyl)-2-(3,6-dihydro-2H-pyran-4-yl)quinolin-5-yl)-5,7-dimethyl-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one | US10899769, Example 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F2N4O2 |
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| Mol. Mass. | 464.507 |
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| SMILES | CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(C3=CCOCC3)c(cc12)C(F)F |t:25| |
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| Structure | 
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