| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [49-170] |
|---|
| Ligand | BDBM480529 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AlphaScreen Assay |
|---|
| IC50 | 2.00±n/a nM |
|---|
| Citation |  Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent US10899769 Publication Date 1/26/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 4 [49-170] |
|---|
| Name: | Bromodomain-containing protein 4 [49-170] |
|---|
| Synonyms: | BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 14593.14 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 49-170 (BRD4-BD1) |
|---|
| Residue: | 122 |
|---|
| Sequence: | ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMG
TIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
TE
|
|
|
|---|
| BDBM480529 |
|---|
| n/a |
|---|
| Name | BDBM480529 |
|---|
| Synonyms: | 3-Cyclopropyl-5,7-dimethyl-1-(3-(2-methylthiazol-5-yl)isoquinolin-8-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one | US10899769, Example 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23N5OS |
|---|
| Mol. Mass. | 429.537 |
|---|
| SMILES | CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
