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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [49-170] | ||
| Ligand | BDBM480611 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | AlphaScreen Assay | ||
| IC50 | 3.00±n/a nM | ||
| Citation |  Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent US10899769 Publication Date 1/26/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [49-170] | |||
| Name: | Bromodomain-containing protein 4 [49-170] | ||
| Synonyms: | BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 14593.14 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 49-170 (BRD4-BD1) | ||
| Residue: | 122 | ||
| Sequence: |
| ||
| BDBM480611 | |||
| n/a | |||
| Name | BDBM480611 | ||
| Synonyms: | 1-(3-(1,3-dimethyl-1H- pyrazol-4-yl)-7- fluoroisoquinolin-8-yl)-5,7- dimethyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5-a] pyrazin-6(5H)-one | US10899769, Example 91a | US10899769, Example 91b | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29FN6O2 | ||
| Mol. Mass. | 488.5566 | ||
| SMILES | CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1cn(C)nc1C |(.6,5.86,;.13,4.39,;-1.38,4.07,;-2.41,5.21,;-1.86,2.61,;-3.34,2.21,;-.82,1.46,;.68,1.78,;1.93,.88,;3.17,1.78,;2.7,3.25,;3.47,4.58,;5.01,4.58,;5.78,5.91,;5.01,7.25,;3.47,7.25,;2.7,5.91,;1.16,3.25,;1.93,-.66,;3.26,-1.43,;4.59,-.66,;3.26,-2.97,;1.93,-3.74,;.59,-2.97,;-.74,-3.74,;-2.07,-2.97,;-2.07,-1.43,;-.74,-.66,;.59,-1.43,;-3.41,-3.74,;-3.41,-5.28,;-4.87,-5.76,;-5.27,-7.25,;-5.78,-4.51,;-4.87,-3.27,;-5.27,-1.78,)| | ||
| Structure | 
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