| Reaction Details |
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 | Report a problem with these data |
| Target | Fascin |
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| Ligand | BDBM350123 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | High Throughput Inhibition Assay |
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| IC50 | 4600±n/a nM |
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| Citation |  Huang, X; Shue, CY Methods for inhibiting fascin US Patent US10941146 Publication Date 3/9/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fascin |
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| Name: | Fascin |
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| Synonyms: | 55 kDa actin-bundling protein | FAN1 | FSCN1 | FSCN1_HUMAN | HSN | SNL | Singed-like protein | p55 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54533.89 |
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| Organism: | Homo sapiens (human) |
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| Description: | n/a |
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| Residue: | 493 |
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| Sequence: | MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAV
CLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLS
CFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLA
FQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTL
KAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDR
DTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKN
GQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFND
GAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKA
SAETVDPASLWEY
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| BDBM350123 |
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| n/a |
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| Name | BDBM350123 |
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| Synonyms: | N-(benzo[d][1,3]dioxol-5- ylmethyl)-2-(4-oxo-1-(S,S- dioxo-tetrahydrothiophen- 3-yl)-1H-pyrazolo[3,4- d]pyrimidin-5(4H)- yl)acetamide | US10208043, # 25 | US10941146, # 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O6S |
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| Mol. Mass. | 445.449 |
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| SMILES | O=C(Cn1cnc2n(ncc2c1=O)C1CCS(=O)(=O)C1)NCc1ccc2OCOc2c1 |
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| Structure | 
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