| Reaction Details |
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 | Report a problem with these data |
| Target | Protein M2-1 |
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| Ligand | BDBM301499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Antiviral Activity |
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| EC50 | 1.58±n/a nM |
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| Citation |  Tahari, A; Vendeville, SM; Jonckers, TH; Raboisson, PJ; Demin, SD; Hu, L Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) US Patent US10131673 Publication Date 11/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein M2-1 |
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| Name: | Protein M2-1 |
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| Synonyms: | Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 22163.59 |
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| Organism: | Human respiratory syncytial virus A (strain A2) |
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| Description: | P04545 |
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| Residue: | 194 |
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| Sequence: | MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEI
SGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEEL
NSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKEST
VSDTNDHAKNNDTT
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| BDBM301499 |
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| n/a |
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| Name | BDBM301499 |
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| Synonyms: | N-(2-(2-(9-(dimethylamino)-5-methyl-5,6,7,8-tetrahydropyrazolo-[1,5-a]pyrido[2,3-d]pyrimidin-2-yl)piperidine-1-carbonyl)-4-methylphenyl)-methane-sulfonamide | US10131673, Compound P26 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35N7O3S |
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| Mol. Mass. | 525.666 |
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| SMILES | CN(C)c1c2CCCN(C)c2nc2cc(nn12)C1CCCCN1C(=O)c1cc(C)ccc1NS(C)(=O)=O |
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| Structure | 
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