Reaction Details |
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Target | Glutaminase kidney isoform, mitochondrial [63-669] |
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Ligand | BDBM416638 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GLS Enzyme Potency Assay |
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IC50 | 20.6±n/a nM |
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Citation | Nissink, JW; Finlay, MR; Charles, MD 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10981904 Publication Date 4/20/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase kidney isoform, mitochondrial [63-669] |
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Name: | Glutaminase kidney isoform, mitochondrial [63-669] |
Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
Type: | n/a |
Mol. Mass.: | 66963.68 |
Organism: | Homo sapiens (Human) |
Description: | O94925 aa 63-669 |
Residue: | 607 |
Sequence: | WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKE
LVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDML
RLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQS
GGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGT
EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
KNLDGLL
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BDBM416638 |
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n/a |
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Name | BDBM416638 |
Synonyms: | (2S)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | US10323028, Example 1(a) | US10981904, Example 1(a) |
Type | Small organic molecule |
Emp. Form. | C22H25FN8O2S |
Mol. Mass. | 484.55 |
SMILES | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1 |r| |
Structure |
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