| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial [63-669] |
|---|
| Ligand | BDBM416681 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | GLS Enzyme Potency Assay |
|---|
| IC50 | 22.6±n/a nM |
|---|
| Citation |  Nissink, JW; Finlay, MR; Charles, MD 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10981904 Publication Date 4/20/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutaminase kidney isoform, mitochondrial [63-669] |
|---|
| Name: | Glutaminase kidney isoform, mitochondrial [63-669] |
|---|
| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 66963.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O94925 aa 63-669 |
|---|
| Residue: | 607 |
|---|
| Sequence: | WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKE
LVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDML
RLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQS
GGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGT
EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
KNLDGLL
|
|
|
|---|
| BDBM416681 |
|---|
| n/a |
|---|
| Name | BDBM416681 |
|---|
| Synonyms: | (2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | US10323028, Example 18(b) | US10981904, Example 18(a) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N7O3S |
|---|
| Mol. Mass. | 467.544 |
|---|
| SMILES | CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
