| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial [63-669] |
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| Ligand | BDBM416684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GLS Enzyme Potency Assay |
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| IC50 | 64.1±n/a nM |
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| Citation |  Nissink, JW; Finlay, MR; Charles, MD 1,3,4-thiadiazole compounds and their use in treating cancer US Patent US10981904 Publication Date 4/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase kidney isoform, mitochondrial [63-669] |
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| Name: | Glutaminase kidney isoform, mitochondrial [63-669] |
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| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
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| Type: | n/a |
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| Mol. Mass.: | 66963.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O94925 aa 63-669 |
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| Residue: | 607 |
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| Sequence: | WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKE
LVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDML
RLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQS
GGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGT
EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
KNLDGLL
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| BDBM416684 |
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| n/a |
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| Name | BDBM416684 |
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| Synonyms: | (2S)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide and (2S)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-methoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide | US10323028, Example 20(a) | US10981904, Example 20(b) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F4N7O3S |
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| Mol. Mass. | 513.469 |
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| SMILES | CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC(F)(F)F)c1 |r| |
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| Structure | 
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