| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Ligand | BDBM493825 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| Ki | 5.08±n/a nM |
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| Citation |  Patel, S; Hamilton, G; Stivala, C; Chen, H; Zhao, G Bicyclic lactams and methods of use thereof US Patent US10988459 Publication Date 4/27/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 [2-375] |
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| Synonyms: | RIP | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase (RIPK1)(2-375) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42278.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546[2-375] |
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| Residue: | 374 |
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| Sequence: | QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALL
EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILE
IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDG
TAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI
KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDV
KSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAP
SLEHPQEENEPSLQ
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| BDBM493825 |
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| n/a |
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| Name | BDBM493825 |
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| Synonyms: | US10988459, Example 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15F3N4O3 |
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| Mol. Mass. | 404.3426 |
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| SMILES | CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O |r| |
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| Structure | 
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