| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [G12D,Q61H] |
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| Ligand | BDBM485666 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 7500±n/a nM |
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| Citation |  Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent US11000515 Publication Date 5/11/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| GTPase KRas [G12D,Q61H] |
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| Name: | GTPase KRas [G12D,Q61H] |
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| Synonyms: | GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 21722.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01116[G12D,Q61H] |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
HEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM485666 |
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| n/a |
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| Name | BDBM485666 |
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| Synonyms: | US10940139, Example 02769 | US11000515, Compound TABLE 7.320 | US11213515, TABLE 7.320 | US11541041, Compound Table 7.299 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClN4O3S |
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| Mol. Mass. | 452.913 |
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| SMILES | Oc1nc(nc2c(csc12)C(=O)N1CCOC(C1)c1ccccc1Cl)-c1ccccn1 |
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| Structure | 
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