Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM497260 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Activity Assay | ||
| IC50 | <3±n/a nM | ||
| Citation |  Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent US11001586 Publication Date 5/11/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM497260 | |||
| n/a | |||
| Name | BDBM497260 | ||
| Synonyms: | (4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(pyridin-4- yl)methanone | US11001586, Example 27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H38N6O2 | ||
| Mol. Mass. | 490.6403 | ||
| SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1 |r,wU:13.12,wD:3.3,16.16,(-8.58,-2.22,;-7.25,-1.45,;-5.92,-2.22,;-4.58,-1.45,;-4.58,.09,;-3.25,-2.22,;-1.91,-1.45,;-1.91,.09,;-.58,.86,;.75,.09,;2.22,.57,;3.12,-.68,;2.22,-1.92,;2.69,-3.39,;4.2,-3.71,;4.68,-5.17,;3.64,-6.32,;4.12,-7.78,;2.14,-6,;1.66,-4.53,;.75,-1.45,;-.58,-2.22,;2.69,2.03,;4.2,2.35,;4.68,3.82,;3.64,4.96,;2.14,4.64,;1.66,3.18,;4.12,6.43,;3.39,7.78,;5.61,6.03,;6.01,4.54,;7.49,4.14,;8.58,5.23,;8.18,6.72,;6.7,7.12,)| | ||
| Structure | 
| ||