| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50461741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 1400±n/a nM |
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| Citation |  Gangjee, A Pyrimidine compounds and pyrimido indole compounds and methods of use US Patent US11001595 Publication Date 5/11/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
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| BDBM50461741 |
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| n/a |
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| Name | BDBM50461741 |
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| Synonyms: | CHEMBL4227112 | US11001595, Compound 6 | US11111252, Compound 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N5OS |
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| Mol. Mass. | 315.393 |
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| SMILES | COc1ccccc1Sc1c(C)c2c(N)nc(N)nc2n1C |
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| Structure | 
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