| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50461737 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TBD |
|---|
| IC50 | 1900±n/a nM |
|---|
| Citation |  Gangjee, A Pyrimidine compounds and pyrimido indole compounds and methods of use US Patent US11001595 Publication Date 5/11/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50461737 |
|---|
| n/a |
|---|
| Name | BDBM50461737 |
|---|
| Synonyms: | CHEMBL4227977 | US11001595, Compound 7 | US11111252, Compound 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17N5OS |
|---|
| Mol. Mass. | 315.393 |
|---|
| SMILES | COc1cccc(Sc2c(C)c3c(N)nc(N)nc3n2C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
