Reaction Details |
| Report a problem with these data |
Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
---|
Ligand | BDBM363525 |
---|
Substrate/Competitor | n/a |
---|
IC50 | 300±n/a nM |
---|
Citation | Lemieux, RM; Popovici-Muller, J; Travins, J; Cai, Z; Cui, D; Zhou, D Therapeutically active compounds and their methods of use US Patent US11021515 Publication Date 6/1/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
---|
Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 46607.23 |
Organism: | Homo sapiens (Human) |
Description: | O75874[R132C] |
Residue: | 414 |
Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
BDBM363525 |
---|
n/a |
---|
Name | BDBM363525 |
Synonyms: | US10640534, Compound 17 | US10689414, Compound 17 | US10717764, Compound 17 | US11021515, Compound 17 | US11667673, Compound 17 | US9850277, Compound 17 |
Type | Small organic molecule |
Emp. Form. | C29H26ClF3N4O4 |
Mol. Mass. | 586.989 |
SMILES | COc1cccnc1N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r| |
Structure |
|