Reaction Details |
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Target | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
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Ligand | BDBM363654 |
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Substrate/Competitor | n/a |
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IC50 | <100±n/a nM |
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Citation | Lemieux, RM; Popovici-Muller, J; Travins, J; Cai, Z; Cui, D; Zhou, D Therapeutically active compounds and their methods of use US Patent US11021515 Publication Date 6/1/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
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Name: | Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] |
Synonyms: | IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 46607.23 |
Organism: | Homo sapiens (Human) |
Description: | O75874[R132C] |
Residue: | 414 |
Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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BDBM363654 |
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n/a |
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Name | BDBM363654 |
Synonyms: | US10640534, Compound 141 | US10689414, Compound 141 | US10717764, Compound 141 | US11021515, Compound 141 | US11667673, Compound 141 | US9850277, Compound 141 |
Type | Small organic molecule |
Emp. Form. | C32H28ClF2N7O3 |
Mol. Mass. | 632.06 |
SMILES | FC1(F)CCC(CC1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2[nH]cnc12)c1ccccc1Cl |r| |
Structure |
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