Reaction Details |
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Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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Ligand | BDBM501443 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 0.340±n/a nM |
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Citation | Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgård, M; Rasmussen, LK; Clementson, CM 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent US11026923 Publication Date 6/8/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
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Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
Synonyms: | 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5 |
Type: | Enzyme |
Mol. Mass.: | 61366.51 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 536 |
Sequence: | MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
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BDBM501443 |
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n/a |
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Name | BDBM501443 |
Synonyms: | 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7- amine | US11026923, Example 74 |
Type | Small organic molecule |
Emp. Form. | C22H27N7O |
Mol. Mass. | 405.4961 |
SMILES | CCOc1ncccc1-c1cc(NCc2ncccn2)c(NC(C)C)c(n1)C(C)=N |
Structure |
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