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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
LigandBDBM484529
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Ki 0.010±n/a nM
Citation Arasappan, A; Cox, JM; Debenham, JS; Hussain, Z; Li, D; Meng, D; Raghavan, S Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors US Patent US11028092 Publication Date 6/8/2021
More Info.:Get all data from this article,  Assay Method
 
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (Human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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  Blast E-value cutoff:
BDBM484529
n/a
NameBDBM484529
Synonyms:US10934294, Example 50 | US10934294, Example 51 | US10934294, Example 52 | US10934294, Example 53 | US10934294, Example 54 | US10934294, Example 55 | US10934294, Example 56 | US10934294, Example 57 | US11028092, Example 57
TypeSmall organic molecule
Emp. Form.C24H22N8O
Mol. Mass.438.4845
SMILESCC(c1ccc(nc1)C1CC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncccn1
Structure
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