Reaction Details |
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Target | Tryptophan 5-hydroxylase 2 |
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Ligand | BDBM445681 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Activity Assay |
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IC50 | 21.0±5 nM |
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Citation | Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent US11028104 Publication Date 6/8/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 2 |
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Name: | Tryptophan 5-hydroxylase 2 |
Synonyms: | NTPH | TPH2 | TPH2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 56055.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_487490 |
Residue: | 490 |
Sequence: | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
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BDBM445681 |
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n/a |
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Name | BDBM445681 |
Synonyms: | Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | US11028104, Example 17 |
Type | Small organic molecule |
Emp. Form. | C25H24N8O2S |
Mol. Mass. | 500.575 |
SMILES | CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O |
Structure |
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