| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 2 |
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| Ligand | BDBM445701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Activity Assay |
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| IC50 | 32.0±2 nM |
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| Citation |  Bader, M; Specker, E; Matthes, S; Schütz, A; Mallow, K; Grohmann, M; Nazaré, M Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same US Patent US11028104 Publication Date 6/8/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 2 |
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| Name: | Tryptophan 5-hydroxylase 2 |
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| Synonyms: | NTPH | TPH2 | TPH2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56055.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_487490 |
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| Residue: | 490 |
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| Sequence: | MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
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|
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| BDBM445701 |
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| n/a |
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| Name | BDBM445701 |
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| Synonyms: | Ex. 37/KM-06-165/(I-37) | US10683309, Example 37 | US11028104, Example 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F2N7O2 |
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| Mol. Mass. | 495.5244 |
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| SMILES | CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)N3CC(F)(F)C3)c2c(=O)[nH]c1=O |
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| Structure | 
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