| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Ligand | BDBM504017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | 0.078±n/a nM |
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| Citation |  Chan, B; Daniels, B; Drobnick, J; Gazzard, L; Heffron, T; Huestis, M; Liang, J; Malhotra, S; Mendonca, R; Rajapaksa, N; Siu, M; Stivala, C; Tellis, J; Wang, W; Wei, B; Zhou, A; Cartwright, MW; Gancia, E; Jones, G; Lainchbury, M; Madin, A; Seward, E; Favor, D; Fong, KC; Good, A; Hu, Y; Hu, B; Lu, A Naphthyridines as inhibitors of HPK1 US Patent US11034692 Publication Date 6/15/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91316.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586597 |
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| Residue: | 833 |
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| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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| BDBM504017 |
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| n/a |
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| Name | BDBM504017 |
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| Synonyms: | (1R,2R)-N-[8-amino-6-(5-hydroxy-2- methylphenyl)-2,7-naphthyridin-3-yl]-2- (1-methyl-1H-pyrazol-4-yl)cyclopropane- 1-carboxamide | US11034692, Compound 287 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N6O2 |
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| Mol. Mass. | 414.4598 |
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| SMILES | Cc1ccc(O)cc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1 |r| |
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| Structure | 
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