| Reaction Details |
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 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
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| Ligand | BDBM479331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 11.0±n/a nM |
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| Citation |  Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors US Patent US11034705 Publication Date 6/15/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| SH2B adapter protein 2 |
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| Name: | SH2B adapter protein 2 |
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| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 67733.52 |
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| Organism: | Human |
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| Description: | O14492 |
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| Residue: | 632 |
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| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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| BDBM479331 |
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| n/a |
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| Name | BDBM479331 |
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| Synonyms: | (6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)-6-(hydroxymethyl)pyrazin- 2-yl)thio)-6a,7,8,9-tetrahydro-6H-pyrido[3,2- b]pyrrolo[1,2-d][1,4]oxazine-8-carbonitrile | US10894797, Compound 20 | US11034705, Compound 20 | US11459340, Compound 29 | US11518772, Compound 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N7O3S |
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| Mol. Mass. | 509.624 |
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| SMILES | C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](C[C@H]5COc34)C#N)nc2CO)[C@@H]1N |r| |
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| Structure | 
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