| Reaction Details |
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 | Report a problem with these data |
| Target | SH2B adapter protein 2 |
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| Ligand | BDBM479357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 3.90±n/a nM |
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| Citation |  Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors US Patent US11034705 Publication Date 6/15/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| SH2B adapter protein 2 |
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| Name: | SH2B adapter protein 2 |
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| Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 67733.52 |
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| Organism: | Human |
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| Description: | O14492 |
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| Residue: | 632 |
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| Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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| BDBM479357 |
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| n/a |
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| Name | BDBM479357 |
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| Synonyms: | (S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-6a,7,8,9- tetrahydro-6H-pyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazin- 4-yl)thio)pyrazin-2-yl)-5,7-dihydrospiro[cyclo- penta[b]pyridine-6,4'-piperidin]-5-amine | US10894797, Compound 46 | US11034705, Compound 46 | US11518772, Compound 46 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35N7O3S |
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| Mol. Mass. | 561.698 |
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| SMILES | COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(Cc6ncccc6[C@H]5N)CC4)ccnc3N2C1 |r| |
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| Structure | 
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