Reaction Details |
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Target | SH2B adapter protein 2 |
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Ligand | BDBM479360 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 12.0±n/a nM |
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Citation | Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors US Patent US11034705 Publication Date 6/15/2021 |
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More Info.: | Get all data from this article, Assay Method |
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SH2B adapter protein 2 |
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Name: | SH2B adapter protein 2 |
Synonyms: | APS | Adapter protein with pleckstrin homology and Src homology 2 domains | SH2 and PH domain-containing adapter protein APS | SH2B2 | SH2B2_HUMAN |
Type: | Protein |
Mol. Mass.: | 67733.52 |
Organism: | Human |
Description: | O14492 |
Residue: | 632 |
Sequence: | MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGAS
FSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSED
VSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLR
LSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFV
PPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVAD
IQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHS
RGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHG
TLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQ
HLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSD
SPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAE
RLLEAVAATAAEEPPEAAPGRARAVENQYSFY
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BDBM479360 |
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n/a |
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Name | BDBM479360 |
Synonyms: | (3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5]decan-8-yl)- 6-(((6aS,8S)-8-((methoxymethoxy)methyl)-6a,7,8,9- tetrahydro-6H-pyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazin- 4-yl)thio)-5-methylpyrazin-2-yl)methanol | US10894797, Compound 49 | US11034705, Compound 49 | US11518772, Compound 49 |
Type | Small organic molecule |
Emp. Form. | C28H40N6O5S |
Mol. Mass. | 572.719 |
SMILES | COCOC[C@H]1C[C@H]2COc3c(Sc4nc(CO)c(nc4C)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1 |r| |
Structure |
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