Reaction Details |
| Report a problem with these data |
Target | Casein kinase I isoform epsilon |
---|
Ligand | BDBM302811 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Kinase Assay |
---|
IC50 | <10±n/a nM |
---|
Citation | Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Casein kinase I isoform epsilon |
---|
Name: | Casein kinase I isoform epsilon |
Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
Type: | Protein |
Mol. Mass.: | 47340.25 |
Organism: | Homo sapiens (Human) |
Description: | P49674 |
Residue: | 416 |
Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
|
|
|
BDBM302811 |
---|
n/a |
---|
Name | BDBM302811 |
Synonyms: | 2-(3-Chlorophenyl)-N5- (4-cyano-3- cyclopropylphenyl)-6,7- dihydropyrazolo[1,5-a] pyrazine-3,5(4H)- dicarboxamide | US9598423, Example A41 |
Type | Small organic molecule |
Emp. Form. | C24H21ClN6O2 |
Mol. Mass. | 460.916 |
SMILES | NC(=O)c1c2CN(CCn2nc1-c1cccc(Cl)c1)C(=O)Nc1ccc(C#N)c(c1)C1CC1 |$;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$| |
Structure |
|