| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase I isoform delta |
|---|
| Ligand | BDBM302851 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase I isoform delta |
|---|
| Name: | Casein kinase I isoform delta |
|---|
| Synonyms: | CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 47356.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48730 |
|---|
| Residue: | 415 |
|---|
| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
|
|
|
|---|
| BDBM302851 |
|---|
| n/a |
|---|
| Name | BDBM302851 |
|---|
| Synonyms: | 7-(tert-Butyl)-2-(3-chloro-4-fluorophenyl)-N-(4-cyanophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-3,5(4H)-dicarboxamide | US9598423, Example A81 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24ClFN6O2 |
|---|
| Mol. Mass. | 494.948 |
|---|
| SMILES | CC(C)(C)[C@@H]1CN(Cc2c(C(N)=O)c(nn12)-c1ccc(F)c(Cl)c1)C(=O)Nc1ccc(cc1)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
