| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM376832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pim Enzyme Assays |
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| IC50 | <100±n/a nM |
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| Citation |  Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as Pim kinase inhibitors US Patent US11053215 Publication Date 7/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM376832 |
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| n/a |
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| Name | BDBM376832 |
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| Synonyms: | N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-03S,4S)-3-fluoro-4-(2-methoxyethoxy)piperidin-1-yl)quinoline-8-carboxamide | US10450296, Example 163 | US11053215, Example 163 | US9920032, Example 163 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37F2N5O3 |
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| Mol. Mass. | 553.6433 |
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| SMILES | COCCO[C@H]1CCN(C[C@@H]1F)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| |
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| Structure | 
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