| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-1 |
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| Ligand | BDBM50233170 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of ATX by Benzene Sulfonamide Series |
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| IC50 | 67.3±9.73 nM |
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| Citation |  Miller, DD; Tigyi, GG; Banerjee, S; Parrill-Baker, AL Autotaxin inhibitors US Patent US11124490 Publication Date 9/21/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-1 |
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| Name: | Ataxin-1 |
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| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
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| Type: | Protein |
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| Mol. Mass.: | 86941.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54253 |
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| Residue: | 815 |
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| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
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| BDBM50233170 |
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| n/a |
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| Name | BDBM50233170 |
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| Synonyms: | CHEMBL4073772 | US11124490, Compound 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14Cl2F2N2O3S2 |
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| Mol. Mass. | 467.337 |
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| SMILES | Fc1ccc(NC(=S)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc1F |
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| Structure | 
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