| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
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| Ligand | BDBM246877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TAM Kinase Assay |
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| IC50 | >3000±n/a nM |
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| Citation |  Li, Y; Burns, DM; Feng, H; Glenn, J; He, C; Mei, S; Pan, J; Wang, X; Ye, Y Pyrrolopyrimidine derivatives as TAM inhibitors US Patent US11136326 Publication Date 10/5/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor TYRO3 |
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| Name: | Tyrosine-protein kinase receptor TYRO3 |
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| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
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| Type: | Protein |
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| Mol. Mass.: | 96894.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06418 |
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| Residue: | 890 |
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| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
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| BDBM246877 |
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| n/a |
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| Name | BDBM246877 |
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| Synonyms: | 4-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-1-yl}-2,5- difluoro-N-[(1S)- 2,2,2-trifluoro-1- methylethyl] benzamide | US10053465, 16 | US10065963, Compound 16 | US10125150, Example 16 | US10336759, # 16 | US10479803, Example 16 | US10519163, Example 16 | US10675284, Example 16 | US11084822, Example 16 | US11130767, # 16 | US11136326, Example 16 | US11214573, Example 28 | US11304949, Compound 16 | US11324749, Comp. No. 16 | US11406640, Comp. No. 16 | US11918581, Compound 16 | US20240058343, Compound 16 | US9611269, Example 28 | US9732097, Example 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19F5N8O |
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| Mol. Mass. | 530.4527 |
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| SMILES | C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F |r| |
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| Structure | 
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