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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA-dependent protein kinase catalytic subunit | ||
| Ligand | BDBM413448 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DNAPK Enzyme Potency Assay (DNA-PK Enz) | ||
| IC50 | <0.100±n/a nM | ||
| Citation |  Finlay, MR; Goldberg, FW; Ting, AK Amino-triazolopyridine compounds and their use in treating cancer US Patent US11136340 Publication Date 10/5/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA-dependent protein kinase catalytic subunit | |||
| Name: | DNA-dependent protein kinase catalytic subunit | ||
| Synonyms: | DNA-PK catalytic subunit | DNA-PKcs | DNA-dependent protein kinase (DNA-PK) | DNA-dependent protein kinase (DNPK) | DNA-dependent protein kinase catalytic subunit (DNA-PK) | DNPK1 | HYRC | HYRC1 | PRKDC | PRKDC_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 469114.78 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P78527 | ||
| Residue: | 4128 | ||
| Sequence: |
| ||
| BDBM413448 | |||
| n/a | |||
| Name | BDBM413448 | ||
| Synonyms: | 9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-7,9-dihydro-8H-purin-8-one | US10407446, Example 1 | US11136340, Example 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H22N8O2 | ||
| Mol. Mass. | 394.4304 | ||
| SMILES | Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1 |r,wU:23.25,wD:20.21,(-.77,3.78,;-2.1,3.01,;-3.44,3.78,;-4.77,3.01,;-6.24,3.49,;-7.14,2.24,;-6.24,1,;-4.77,1.47,;-3.44,.7,;-2.1,1.47,;-.77,.7,;.56,1.47,;.56,3.01,;1.9,3.78,;3.23,3.01,;4.7,3.49,;5.17,4.95,;5.6,2.24,;7.14,2.24,;4.7,1,;5.09,-.49,;4.01,-1.58,;4.4,-3.07,;5.89,-3.47,;6.29,-4.95,;6.98,-2.38,;6.58,-.89,;3.23,1.47,;1.9,.7,)| | ||
| Structure | 
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