| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclic AMP-dependent transcription factor ATF-4 |
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| Ligand | BDBM524151 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Expression Inhibition Assay |
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| IC50 | 268±n/a nM |
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| Citation |  Delgado Oyarzo, LM; Ureta Díaz, GA; Pujala, B; Panpatil, D; Bernales, S; Chakravarty, S Inhibitors of integrated stress response pathway US Patent US11166942 Publication Date 11/9/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclic AMP-dependent transcription factor ATF-4 |
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| Name: | Cyclic AMP-dependent transcription factor ATF-4 |
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| Synonyms: | ATF4 | ATF4_HUMAN | Activating transcription factor 4 | CREB-2 | CREB2 | Cyclic AMP-responsive element-binding protein 2 | TXREB | Tax-responsive enhancer element-binding protein 67 | TaxREB67 | cAMP-dependent transcription factor ATF-4 | cAMP-responsive element-binding protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 38573.48 |
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| Organism: | Human |
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| Description: | P18848 |
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| Residue: | 351 |
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| Sequence: | MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE
WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC
DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL
ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG
SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
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| BDBM524151 |
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| n/a |
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| Name | BDBM524151 |
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| Synonyms: | US11166942, Compound 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25Cl2F2N3O4 |
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| Mol. Mass. | 504.354 |
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| SMILES | O[C@@H](CNC1CCN(CC1)NC(=O)COc1ccc(Cl)c(F)c1)COc1ccc(Cl)c(F)c1 |r| |
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| Structure | 
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