| Reaction Details |
|---|
 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
|---|
| Ligand | BDBM525658 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Surface Plasmon Resonance (SPR) Assay |
|---|
| Kd | 5.50±n/a nM |
|---|
| Citation |  Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Substituted carboxamides as inhibitors of WDR5 protein-protein binding US Patent US11174250 Publication Date 11/16/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| WD repeat-containing protein 5 |
|---|
| Name: | WD repeat-containing protein 5 |
|---|
| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36597.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61964 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
|
|
|
|---|
| BDBM525658 |
|---|
| n/a |
|---|
| Name | BDBM525658 |
|---|
| Synonyms: | US11174250, Example 76 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H33F4N5O3 |
|---|
| Mol. Mass. | 587.6083 |
|---|
| SMILES | CN(Cc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)[C@H]1CCOC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
