| Reaction Details |
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 | Report a problem with these data |
| Target | PEX5-related protein/Peroxisomal membrane protein PEX14 |
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| Ligand | BDBM304002 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Antitrypanosomal Activity Assay |
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| IC50 | 30470±n/a nM |
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| Citation |  Sattler, M; Popowicz, G; Dawidowski, M; Emmanouilidis, L; Erdmann, R; Schliebs, W; Kalel, V Pyrazolopyridine derivatives and their use in therapy US Patent US10138242 Publication Date 11/27/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| PEX5-related protein/Peroxisomal membrane protein PEX14 |
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| Name: | PEX5-related protein/Peroxisomal membrane protein PEX14 |
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| Synonyms: | PEX14-PEX5 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Peroxisomal membrane protein PEX14 |
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| Synonyms: | PEX14 | PEX14_HUMAN | PTS1 receptor-docking protein | Peroxin-14 | Peroxisomal membrane anchor protein PEX14 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41218.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75381 |
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| Residue: | 377 |
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| Sequence: | MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTD
EEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIA
FGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQ
QQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPS
WQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGE
GVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQ
VEKLRRPEGASNESERD
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| Component 2 |
| Name: | PEX5-related protein |
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| Synonyms: | PEX2-related protein | PEX5-like protein | PEX5L | PEX5R | PEX5R_HUMAN | PXR2 | Peroxin-5-related protein | Peroxisome biogenesis factor 5-like | Pex5Rp | TRIP8b | Tetratricopeptide repeat-containing Rab8b-interacting protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 69680.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8IYB4 |
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| Residue: | 626 |
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| Sequence: | MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPL
LTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQ
TQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDV
KFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAP
TQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQ
EAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDA
EAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNW
IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGL
GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG
FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSL
MDQPELFQAANLGDLDVLLRAFNLDP
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| BDBM304002 |
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| n/a |
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| Name | BDBM304002 |
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| Synonyms: | US10138242, Compound 88 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O |
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| Mol. Mass. | 399.4882 |
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| SMILES | Cn1nc2CCN(Cc3c[nH]c4ccccc34)Cc2c1C(=O)NCc1ccccc1 |
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| Structure | 
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