Reaction Details |
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Target | Tyrosine-protein kinase JAK2 [828-1132] |
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Ligand | BDBM262166 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro JAK Kinase Assay |
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IC50 | 25±n/a nM |
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Citation | Yao, W; Burns, DM; Zhuo, J Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors US Patent US11214573 Publication Date 1/4/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK2 [828-1132] |
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Name: | Tyrosine-protein kinase JAK2 [828-1132] |
Synonyms: | JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 |
Type: | n/a |
Mol. Mass.: | 35579.28 |
Organism: | Homo sapiens (Human) |
Description: | O60674[828-1132] |
Residue: | 305 |
Sequence: | GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
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BDBM262166 |
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n/a |
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Name | BDBM262166 |
Synonyms: | 5-{3-(cyanomethyl)- 3-[4-(1H-pyrrolo[2,3- b]pyridin-4-yl)-1H- pyrazol-1-yl] azetidin-1-yl}-N- isopropylpyrazine- 2-carboxamide | US10065963, Compound 17 | US10125150, Example 17 | US10336759, # 17 | US10479803, Example 17 | US10513522, Example 34 | US10675284, Example 17 | US11084822, Example 17 | US11130767, # 17 | US11136326, Example 17 | US11214573, Example 34 | US11304949, Compound 17 | US11324749, Comp. No. 17 | US11406640, Comp. No. 17 | US11596632, Comp. No. 17 | US11918581, Compound 17 | US20240058343, Compound 17 | US9611269, Example 34 | US9708333, 17 | US9732097, Example 17 |
Type | Small organic molecule |
Emp. Form. | C23H23N9O |
Mol. Mass. | 441.4884 |
SMILES | CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12 |
Structure |
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