Reaction Details |
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Target | Mixed lineage kinase domain-like protein |
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Ligand | BDBM534410 |
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Substrate/Competitor | n/a |
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Meas. Tech. | MLKL Phosphorylation High-Content Assay |
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IC50 | 0.60±n/a nM |
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Citation | Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPOWO2022086828 Publication Date 4/28/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Mixed lineage kinase domain-like protein |
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Name: | Mixed lineage kinase domain-like protein |
Synonyms: | MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL |
Type: | PROTEIN |
Mol. Mass.: | 54493.57 |
Organism: | Homo sapiens |
Description: | ChEMBL_104428 |
Residue: | 471 |
Sequence: | MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
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BDBM534410 |
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n/a |
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Name | BDBM534410 |
Synonyms: | (S)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3-(4-chlorophenyl)-3-hydroxypropyl)-2,4-dimethylbenzamide | WO2018148626, Example 146 | WO2022086828, Example 146 |
Type | Small organic molecule |
Emp. Form. | C24H24ClN5O2 |
Mol. Mass. | 449.933 |
SMILES | Cc1cc(C)c(cc1C(=O)NCC[C@H](O)c1ccc(Cl)cc1)-c1ccn2nc(N)nc2c1 |r| |
Structure |
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