| Reaction Details |
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 | Report a problem with these data |
| Target | Mixed lineage kinase domain-like protein |
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| Ligand | BDBM534557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MLKL Phosphorylation High-Content Assay |
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| IC50 | 1.20±n/a nM |
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| Citation |  Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPOWO2022086828 Publication Date 4/28/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mixed lineage kinase domain-like protein |
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| Name: | Mixed lineage kinase domain-like protein |
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| Synonyms: | MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54493.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104428 |
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| Residue: | 471 |
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| Sequence: | MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
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| BDBM534557 |
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| n/a |
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| Name | BDBM534557 |
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| Synonyms: | 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-2-fluoro-N-(l-fluoro-4-(4-fluorophenyl)-4-hydroxybutan-2-yl)-6-methylbenzamide | WO2022086828, Example 293 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16ClF4N5O2 |
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| Mol. Mass. | 493.841 |
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| SMILES | Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NC[C@@H](O)C(F)(F)c2ccc(F)cc2)c1F |r| |
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| Structure | 
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