| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mixed lineage kinase domain-like protein |
|---|
| Ligand | BDBM534555 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | MLKL Phosphorylation High-Content Assay |
|---|
| IC50 | 2.40±n/a nM |
|---|
| Citation |  Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPOWO2022086828 Publication Date 4/28/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mixed lineage kinase domain-like protein |
|---|
| Name: | Mixed lineage kinase domain-like protein |
|---|
| Synonyms: | MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 54493.57 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_104428 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
|
|
|
|---|
| BDBM534555 |
|---|
| n/a |
|---|
| Name | BDBM534555 |
|---|
| Synonyms: | 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3,3-difluoro-3-(4-fluorophenyl)-2-hydroxypropyl)-2-fluoro-6-methylbenzamide | WO2018148626, Example 291 | WO2022086828, Example 291 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H19F4N5O2 |
|---|
| Mol. Mass. | 473.4229 |
|---|
| SMILES | Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC[C@H](O)C(F)(F)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
