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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase pim-1 | ||
| Ligand | BDBM377169 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Pim Enzyme Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  Xue, C; Li, Y; Feng, H; Pan, J; Wang, A; Zhang, K; Yao, W; Zhang, F; Zhuo, J Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent US11229631 Publication Date 1/25/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase pim-1 | |||
| Name: | Serine/threonine-protein kinase pim-1 | ||
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 35681.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11309 | ||
| Residue: | 313 | ||
| Sequence: |
| ||
| BDBM377169 | |||
| n/a | |||
| Name | BDBM377169 | ||
| Synonyms: | N-{4-[(3S)-3-Aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 22-1 | US10517858, Example 22 (Diastereoisomer 1) | US10828290, Example 22 (Diastereoisomer 1) | US11229631, Example 22 Diastereoisomer 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24F3N5O2 | ||
| Mol. Mass. | 483.4856 | ||
| SMILES | N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:1.0,11.12,(-5.48,3.29,;-4.15,2.52,;-2.82,3.29,;-1.48,2.52,;-1.48,.98,;-2.82,.21,;-4.15,.98,;-2.82,-1.33,;-4.15,-2.1,;-5.61,-1.62,;-6.52,-2.87,;-5.61,-4.11,;-6.01,-5.6,;-4.15,-3.64,;-2.82,-4.41,;-1.48,-3.64,;-1.48,-2.1,;-.15,-1.33,;1.18,-2.1,;1.18,-3.64,;2.52,-1.33,;3.85,-2.1,;5.19,-1.33,;5.19,.21,;6.52,.98,;3.85,.98,;2.52,.21,;3.85,2.52,;2.52,3.29,;1.18,2.52,;2.52,4.83,;3.85,5.6,;5.19,4.83,;5.19,3.29,;6.52,2.52,)| | ||
| Structure | 
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